LB Tanner Vallejo suffered a shoulder injury and was unable to finish the game.
DE Eddie Yarbrough, one of the surprises of camp, started in place of Shaq Lawson and registered three tackles, a sack, and a deflected pass.
DE Shaq Lawson was inactive due to a lingering groin issue.
QB Nathan Peterman's NFL debut went pretty well as he completed 13 of 25 passes for 112 yards and a touchdown.
LB Reggie Ragland, demoted to third team earlier in the week, led the Bills with six tackles, one for a loss.
RB Jonathan Williams started in place of LeSean McCoy and carried four times for 39 yards, but also tweaked a hamstring and is listed as day-to-day.
RB LeSean McCoy was held out of the preseason opener, even though he's not injured.
QB Tyrod Taylor completed 5 of 8 passes for 46 yards and was sacked once, a play after which he got up limping, though he was able to continue and play three full series.
FS Bacarri Rambo suffered a hamstring injury and head coach Sean McDermott thinks it could be a couple weeks before he's back.