S Landon Collins (ankle) was not present at the start of practice Wednesday and didn't practice. Collins told reporters that he believes he'll be good to go on Sunday.
RB Paul Perkins (ribs) did not practice Wednesday and is potentially facing missing his second straight game.
WR Sterling Shepard (ankle) is currently in a walking boot and is unable to practice. The Giants have listed Shepard as day-to-day, but it's unlikely that he will play Sunday night against the Broncos.
CB Eli Apple, benched for three defensive series last week, complained about being unfairly targeted and opined that the culture had to change.
LB Jonathan Casillas (neck) did not practice Wednesday. Casillas suffered a burner last week.
DE Olivier Vernon (ankle) remains unable to practice. Vernon was initially injured in Week 3; he aggravated his injury in Week 4 and has not been able to practice since.
C Weston Richburg (concussion) is making progress in the protocol, but has still not been cleared to return to light drills.